Mean platelet volume as an inflammatory marker in patients with chronic periodontitis- a pilot study

MPV as inflammatory marker in chronic periodontitis

Abstract

Background: Periodontitis is a widespread infectious disease of the periodontium that leads to gingival inflammation and bleeding. It has become the leading cause of tooth loss in adults. Mean platelet volume (MPV), an important index of platelet activity, reflects platelet production rate and stimulation. MPV has been considered an inflammatory marker in many chronic diseases and might reflect disease activity of periodontitis. It was also known that elevated MPV is associated with cardiovascular diseases (CVD). The aim of the present study was to investigate the relationship between MPV and chronic periodontitis and short term effects of active periodontal treatment on MPV level.

Methods: 13 subjects with chronic generalized periodontitis were selected from OPD, Department of Periodontics, Kamineni institute of dental sciences. All subjects received periodontal and hematological examinations at baseline and 1week. Active periodontal treatment (APT) was administered in all the subjects

Results: Decrease of MPV was related to the severe periodontal inflammation, and the value inversed shift after active APT.

Key message: MPV can be used as a diagnostic marker in diagnosing patients with periodontitis and also can be used as a non pharmacological intervention in improving the platelet activity.